研究进展

   Magnetic Iron Oxide Nanoparticles Applied in Magnetic Fluid Hyperthermia Therapy

Hyperthermia is a therapeutic procedure used to raise the temperature of a region of the body affected by cancer. The rationale is based on a direct cell-killing effect at temperatures above 42°C. Our studies are focused on magnetic fluid hyperthermia (MFH) which applying magnetic fluid as heating media for cancer treatment.

Fe3O4 particles with different diameters synthesized by sol-gel method

Size-dependence of SAR values for magnetite particles in AC magnetic field

 

 

An optimized magnetic nanoparticle, Glutamic acid-modified maghemite nanoparticle labeled Fe2O3-Glu, was obtained applied in magnetic fluid hyperthermia

 

 

Toxicity of Fe2O3-Glu nanoparticles

Acute Toxicity

Animal: white mouse, five dosage groups, tail vein injection

 

MFH experiments in vitro and in vivo

Experiments in vitro

The magnetic hyperthermia therapy with Fe2O3-Glu magnetic nanoparticles has obvious curative effect for mouse subcutaneous explanting hepatic carcinoma.